Kent Peterson
Fluid Imaging Technologies Inc., USA
Title: The use of flow imaging microscopy for nanoparticle analysis in biopharmaceuticals
Biography
Biography: Kent Peterson
Abstract
Flow imaging microscopy has proven to be an important tool for the analysis of subvisible particulates in parenteral drugs. Now, due to the combined resolving power of blue LED light and patented oil immersion technology, flow imaging microscopes can image and analyze particles as small as 300 nm. The ability to detect transparent particles and differentiate them based on morphology yields significantly more detailed and accurate information than can be acquired using common laser diffraction and light obscuration techniques. Along with sophisticated statistical pattern recognition algorithms, these systems can be used to distinguish between different particulate types such as silicon oil, protein aggregates, and air bubbles. This presentation will present the techniques used to accomplish this.