Muthu Madaswamy Sona
University of Singapore, India
Title: Nanotheranostics: TPGS micelles for early diagnosis and therapy of cancer
Biography
Biography: Muthu Madaswamy Sona
Abstract
Nanotheranostics have shown the development of advanced platforms that can diagnose cancer at early stages, initiate first-line therapy, monitor it, and if needed, rapidly start subsequent treatments. In nanotheranostics, therapeutic and diagnostic agents are loaded with nanomedicine in a single theranostic platform, which can be further developed as clinical formulations for targeting different types of cancer. This speech is concerned about theranostic micelles developed using TPGS (tocopheryl polyethylene glycol succinate), docetaxel and gold nanoclusters for the early diagnosis and therapy of cancer with advanced features. Micelles are amphiphilic spherical nanostructures consisting of hydrophilic shell and hydrophobic core. Micelles have advantages such as thermodynamic stability, kinetic stability, higher payload and smaller dimension (less than 50 nm). In our group, various research studies were done on targeted micelles for cancer diagnosis and therapy. In future, nanotheranostics will be able to provide personalized treatment which can make cancer even curable or at least treatable at the earliest stage.