25^th Nano Congress for Future Advancements

Biography

Biography: Nilay Kahya

Abstract

Alginate is a biopolymer which is used in several biomedical applications by means of its favorable properties, such as biodegradability, biocompatibility and non-toxicity. In the present study, the availability of alginate gel to encapsulate and release a protein type drug was investigated. The use of alginate has been reported before for the controlled release of bovine serum albumin (BSA), however favorable controlled release behavior was only achieved by the help of clay incorporation to alginate beads. Recently, it was reported that incorporation of anionic surfactant, sodium dodecyl sulfate (SDS) into alginate increases the Young’s modulus of the alginate beads. Moreover, SDS and bovine serum albumin interaction via complexation mechanism was reported. In the light of the last two works, SDS was incorporated into alginate beads to enhance protein-loading efficiency of hydrogel and to prevent the burst release of protein drug. Bovine serum albumin (BSA) was used as model protein drug. It was found that SDS modified calcium alginate beads encapsulated almost the initial amount of loaded drug. The protein release experiments were done in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Results of release experiments showed that SDS modified alginate beads showed controlled and time efficient drug release. Characterization of the beads was performed by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), and swelling experiments, respectively.