33^rd Nano Congress for Future Advancements April 28-29, 2021 London, UK

Junhui Hu received his Ph.D. Degree from Tokyo Institute of Technology, Japan, in 1997, and B. E. and M. E. degrees from Zhejiang University, China, in 1986 and 1989, respectively. Currently he is a Chang-Jiang Distinguished Professor, and the deputy director of a State Key Laboratory in Nanjing University of Aeronautics and Astronautics, China. His research interest is in ultrasonic sensors and actuators, ultrasonic manipulations, etc. He is the author and co-author of more than 300 papers, disclosed patents and books, including more than 100 SCI journal papers. He is also the sole author of monograph “Ultrasonic Micro/Nano Manipulations”.

Gas identification by a single sensing element is a challenging and promising technology. In this report, we demonstrate a novel gas identification strategy, which is based on a single-sensor sensor radiated by ultrasound. The identification is based on different ultrasonic catalysis effect on the steady sensing responses of an ultrasonically radiated MOS or catalytic combustible gas sensor to different gase analytes. It does not need a complicated feature extraction computation. Our experiments show that the success rate of identification can be up to 100% if strong enough ultrasound is employed. The identification process can also measure the concentration of the gas to be identified. The identification result is immune to the interference of impurity gases to some extent. The anti-interference capability can also be strengthened by increasing the ultrasonic vibration velocity.

Thomas Prevenslik is a retired American living in Berlin. He developed simple QED nanoscale heat transfer in Hong Kong in 2010. Having nothing to do with Feynman's QED, simple QED conserves heat by emitting EM radiation instead of changing temperature, the EM radiation standing inside the NP. For a spherical NP, simple QED creates a quantum state E = hc/2nd, where h is Planck's constant, c the velocity of light, with n and d the refractive index and diameter of the NP.

The CDC approach to the Covid-19 virus was to quickly develop a vaccine which even if successful in the near term would be impossible to implement for the ~8 billion people in the world, let alone unacceptable because of attendant social unrest and economic collapse. In mid-2020, a new approach for Covid-19 and other viruses called the Nanoparticle Treatment was proposed targeting

only a relatively small number of patients who tested positive for the virus. Messenger mRNA and antigens of the virus having unknown side effects were excluded. Only injections of biodegradable lipid nanoparticles (NPs) in saline are used with the antigen being the actual live Covid-19 virus in the tested positive patient that is inactivated by the UV radiation emitted from the NPs. The UV is produced by the simple QED theory based on the Planck law which denies atoms in NPs the heat capacity to conserve heat by an increase in temperature, and instead heat from the surroundings is conserved by creating EM radiation at a wavelength depending on the NP size, e.g., 80 nm lipid NPs emit UVC (254 nm) radiation. In the manner of an in vivo vaccine, the NP treatment uses UVC to inactivate the live Covid-19 virus in the patient to produce the inactivated virus that acts as the antigen to elicit immunity to current and future Covid-19 infections. By controlling the NP dose, the UVC is held to low levels of collateral DNA damage allowing recovery by DNA repair systems that evolved during the UV intense primitive Earth. Today, the Pfizer-BioNTech vaccine and others having over 90% efficacy are found to lose immunity prompting re-vaccinations. However, the NP treatment, especially in pill form to avoid injections, is suggested as sufficent and economic to be administered as many times necessary to all Covid-19 patients on Earth tested positive to extend immunity as envisoned in mid-2020.

Valentyn Nastasenko, Kherson State Maritime Academy Ukraine, faculties’ Engineering and electronics, the department of transport technologies and mechanical engineering. Dr. Technical sciences, Professor. A sphere of scientific interests includes quantum physics, the theory of gravitation, fundamentals of the material world and the birth of the Universe, the author of more than 70 scientific works in these spheres.

Currently, there is no more important problem for humanity than the fight against SARS-CoV-19 (COVID-19). Information of researchers from the Massachusetts Institute of Technology that the virus envelope quickly degrades at frequencies of 25 and 50 MHz, both in water and air is appeared. However, little attention has been paid to this message. The purpose of this work is to eliminate this drawback and draw attention to a new way of fighting viruses and bacteria by their resonant destruction. This path was founded back in the XX century Alexander Gurvich (Russia) and Royal Rife (USA) and implemented in a number of already invented electronic devices. Royal Rife used this path to treat cancer patients, but in a number of cases he received a negative result, which forced them to reject this path (not without the influence of pharmaceutical companies, due to the threat of losing the market for expensive drugs). Given that COVID-19 is rapidly mutating, it requires the production of billions of doses of new types of vaccines, which is carried out "in pursuit" of mutations. This path requires constant new costs of intellectual, material, technical and economic resources, which are diverted from other areas of improving human life and activities. In addition, during the "in pursuit" period, there are no other more effective methods of combating COVID-19 than isolation, which has a detrimental effect on the economy countries and people's living conditions. Since these problems are more important than other immediate benefits, therefore, it is necessary to forget about past failures and direct all efforts to developing a new path - the resonant destruction of viruses, as a universal disinfectant for all types of viruses. This does not reject the development of new vaccines and traditional methods of treatment; they can be carried out in parallel. The developed individual electronic devices can be made in the form of medallions or additional microchips of smartphones and mobile phones, which are available to all inhabitants of the Earth. If the same resources that were used to develop vaccines are involved in solving this problem, success is possible within a year, and further costs will be minimal.

Maria Vorobyeva is junior researcher of International Intergovernmental Organization Joint Institute for Nuclear Research. In the last three years, she has been very actively involved in lipid-protein interactions in model lipid membranes. Whereas the addition of various molecules to the membrane can change its physical properties and alter its structure, that in turn may affect its functionality. It is thus crucial to know the origin of these changes, and understand the intermolecular interactions responsible for embedding the various additives to the membrane. Of course, the influence of membrane functionality can go in both directions.

The history of technology in the past three hundred years has been one of major leaps forward, compared with the two thousand years or so that preceded them. In the 18th Century, the Agricultural Revolution changed the nature of farming throughout the world. Formerly, the "three field" system had been a dominant feature of agriculture, with the result that productivity was only two-thirds of what it might have been. The addition of fertilizers, irrigation, and upgraded equipment, such as steel plows, for everyday use meant that the "three field" system could be abandoned. It was, and it was replaced by a system that is much more recognizable in the modern day. The Agricultural Revolution, once production exceeded immediate consumption levels, allowed for society to begin to consider other aspects of the economy. The obvious choice was to look at industrial diversification beyond the "cottage industry" model. This became the Industrial Revolution of the 19th Century, though it actually had its roots in the 18th. When grist mills with wind and power looms with water power came into general use at that time, the stage was set for the Industrial Revolution to burst forth in the next century. Of course, it was not long before wind and water were replaced by the steam engine as a source of power. Once they became mobile for boats and railroads, steam engines rapidly dominated the ability of society to adapt to a wide range of environments that it could not have in earlier times. At the same time, industries such as steel, coal, and, later, oil supported this diversity well into the 20th Century. Ironically, it took two world wars to foster a shift from the "hard" Industrial Revolution to what might be termed the "soft" Industrial Revolution characterized by computers and circuit boards.

Nabeel does research in Applied Mathematics, Solid State Physics, and Nanotechnology, A specialty is 'Electrospinning' Nabeel teacher of physics in Gifted Students School in Anbar, Iraq. He is currently PhD student in Institute of Nano-Optoelectronics Research and Technology (iNOR)-Malaysia.

The Human is the most important creature in this great universe. This great human organs of the body and the cells, it is threatened the existence of diseases that afflict him, and we know for sure that this great body the ability toresist most diseases. It is known that some diseases triumph over this great body and an example of this is cancer, so in many cases their lives end of many humans because of the disease. My study today is a simple report and a call to all researchers to turn to the important thing that is the intelligence of human body cells, which I believe to tell us of any damage that tries to harm this body. The body that tells us when it needs to water by thirst state, moreover, why do we choose a specific type of eating or a specific fruit can tell us about cancer early, all of this is a translation of what the body needs. So we need to listen and translate what are cells need to understand much of what happens to the body, and also very early detection of most cancers that occur to the body.

NOUJ Nisrine and the lab team used their expertise to solve a big problem in the region of Agadir, Morocco. Treat environmentally harmful leachate using a simple and inexpensive method. A combination of an abundant biocoagulant and infiltration-percolation on sand shows promising results in terms of reducing pollutants. This approach could easily be used and save the environment.

In Morocco, the increasing production of municipal solid waste (MSW) and its by-products, in particular leachate, is a major concern. MSW leachate is a very complex effluent, loaded with organic and inorganic pollutants; it poses a serious threat to human health and the environment. In Agadir city, the leachate generated is stored in seven tanks in the Tamellast land-fill. The daily flow of this effluent accelerates the saturation of the storage tanks. Overflowing leachate presents a potential environmental hazard, and proper treatment of the leachate has inevitably become a requirement. Therefore, this study aims to find a simple, inexpensive and efficient leachate treatment system. Two techniques using local natural materials have been combined to achieve significant results: coagulation and infiltration-percolation. Cactus powder and cactus mucilage have been selected to treat leachate by coagulation and titaniferous sand as a filter material for the infiltration-percolation process. Laboratory scale experiments show very interesting results. Due to its effectiveness at a dose of 20 mg / l at pH 11, the effluent treated with cactus mucilage was chosen to undergo secondary treatment (86.54% for turbidity and 14.60% for electrical conductivity). The elimination of turbidity and electrical conductivity achieved after infiltration-percolation is, respectively, 97% and 39%.

The interaction of the CO with Pd cluster is still poorly characterized in both theoretical and experimental studies. In this study Pd cluster is chosen because it presents a great ability to adsorb and store molecule such as hydrogen, oxygen as a good catalyst and is used to speed up hydrogenation and dehydrogenation reaction. Pd nowadays is more and more used in electrical applications; such as: wide screen, television, computer and mobile phone. CO was found to be highly toxic for both humans and animals. And the atmosphere receives an enormous amount of CO per year (1.09 billion tons in 2000). In this way CO dissociation is an essential step in the minimization of this pollutant.

The structure of the clusters was obtained by the thermal quenching techniques. The potential energy of the CO molecules was obtained by an embedded–atom potential also the reaction between the CO and Pd is modeled by LEPS (London-Eyring-Polanyi-Sato) function. The chemisorption probability has calculated as a function of impact parameters, collision energies, and rovibrational initial state. The dissociative probability of the CO was also studied. As a result of this study the molecules that reach the cluster with high translation energy (for example0.8eV) will have greater dissociation probability when interacting with atoms near the center of mass of the cluster i.e. at impact parameter b=0 .This probability decrease successively with the increase in the impact parameter till it reach its minimum value at 4.25 The molecule interact at lower translation energy (as example0.01eV) have the least dissociation probability, but they dissociate at large impact parameter than the former one which clearly sign for the area of indirect dissociation.

Linda Jeeva Kumari Henry is a doctoral research scholar at the Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), University College of Engineering (UCE), Anna University, Tiruchirappalli, Tamil Nadu, India. Her specializations include pulmonary pharmacology, drug delivery, cell culture and molecular biology. She has worked as a junior research fellow in the Government of India sponsored National Facility for Drug Development, and has handled the responsibility of organizing cell culture facility, laboratory of pulmonary research. Her research focuses on developing targeted drug delivery system for the management of asthma. She has actively participated and presented papers in various national and international conferences. She has published eleven research articles in peer-reviewed journals with a cumulative impact factor of 32.459. Her passion is to explore the potentials offered by nanotechnology in the arena of translational medicine that could benefit the society, thereby improving the quality of human life.

Statement of the Problem: Asthma is a chronic inflammatory lung disease which is characterized by airway hyperresponsiveness, airway inflammation and goblet cell hyperplasia. It affects about 339 million people globally with an estimation of an additional 100 million asthmatics by 2025. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear hormone receptor that acts as a therapeutic target for asthma. PPARγ agonists are shown to combat inflammatory responses in asthma pathogenesis. Synthetic PPARγ agonists like thiazolidinediones impose various adverse effects, hence we opted for a phytocompound over conventional drugs. Fisetin, a PPARγ agonist is a highly hydrophobic flavonoid present in many fruits and vegetables that possesses anti-asthmatic property. However, poor aqueous solubility limits its pharmacological activity. Nanoparticle-based drug delivery systems are developed to target alveolar macrophages associated with pulmonary inflammation. Polymeric nanoparticles are biocompatible, safe and stable with sustained release property for better therapeutic effect. Therefore, the purpose of the study is to develop fisetin-loaded polymeric nanoparticles (Fis-Nps) and explore the anti-asthmatic effect of encapsulated fisetin over free fisetin via PPARγ-dependent pathway. Methodology & Theoretical Orientation: Fis-Nps were prepared by nanoencapsulation technique. Physiochemical characterizations, in vitro drug release and hemocompatibility studies were performed. In vivo anti-asthmatic studies of aerosolized Fis-Nps in ovalbumin-induced BALB/c mice model via inhalation route of administration were performed. PPARγ-mediated anti-asthmatic action of Fis-Nps was elucidated by protein expression studies (western blot). Findings: Inhalation administration of Fis-Nps remarkably ameliorated airway hyperresponsiveness, inflammatory cells, pro-inflammatory cytokines, nitric oxide, reactive oxygen

species, eosinophil peroxidases and serum IgE, thereby attenuating the disease progression in asthma via up-regulation of PPARγ. Conclusion & Significance: Nanoencapsulated Fis-Nps exhibits better anti-asthmatic activity over free fisetin wherein PPARγ plays a master regulator. Thus, the pharmacological potential of fisetin is significantly enhanced by nanoencapsulation and the targeted delivery of aerosolized nanoformulation leads to an effective asthma control strategy.

Toxicity of lead remains a topical issue even in the developed economies of the world. The challenges posed by this metal are informed by its near ubiquitous presence in both domestic and industrial appliances. Among the several organs vulnerable to the toxicity of this metal is the kidney especially in occupationally predisposed adults where due to lack of very sensitive indicators

of its toxicity, the pathology often present late as end-stage-renal disease (ESRD) by which time the damage to the kidney is irreversible. This presentation is to chronicle the chemistry of this metal and biochemistry of its disease especially in the vulnerable group with a view to highlighting the synergy between basic sciences and medicine and the need to explore this in translational research in the quest for early and sensitive bioindicator of aetiopathology of exposure to the metal, lead.